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FLAGYL ER tablets should not be administered to patients with severe (Child-Pugh C) hepatic impairment unless it is deemed that the benefits flagyl outweigh the risks in these patients . Following a single intravenous infusion of 500 mg metronidazole, the mean AUC24 of metronidazole was higher by 114% in patients with severe (Child-Pugh C) hepatic impairment, and by 54% and 53% in patients with mild (Child-Pugh A), and moderate (Child-Pugh B) hepatic flagyl impairment, respectively, compared to healthy control subjects . flagyl No dosage adjustment is needed for patients with mild to moderate hepatic impairment . Patients with hepatic impairment who receive the usual recommended dose of FLAGYL flagyl ER tablet should be monitored for metronidazole associated adverse events (see PRECAUTIONS and DOSAGE AND ADMINISTRATION) . There were no significant changes in the AUC24 of hydroxyl-metronidazole flagyl in these hepatically impaired patients .

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