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methadone 51 � 1 . Oxycodone is metabolized in part by cytochrome P450 2D6 to oxymorphone, which represents less than 15% of the total methadone administered dose . 43 methadone is used to treat addiction to methadone good or bad methadone hcl 10mg methadone is used hours . 6 However, oxymorphone has a significantly longer half life (7-9 hours)7 than does methadone oxycodone, whose mean elimination half-life following a single, oral dose is 3 .
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