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However, no evidence of genotoxic potential was observed in a range of other in vitro tests, including assays for gene mutation in bacteria, yeast, or in a second mammalian cell revia line, a chromosomal aberration assay, and an assay for DNA damage in human cells . Naltrexone did not exhibit clastogenicity in revia an in vivo mouse micronucleus assay . There was limited evidence of a weak genotoxic effect of naltrexone in one gene mutation assay in a mammalian cell line, in the Drosophila recessive lethal assay, and in revia non-specific DNA repair tests with E .